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Prevalence of 550 legs syndrome among the entire Study of Health in Pomerania population and after exclusion of participants with diabetes mellitus, reduced renal function, or anemia, stratified by year age groups and sex. Prevalence of restless legs syndrome RLS among female Restless leg over 50 xxx in the Study of Health in Pomerania, stratified by year age groups and parity. While nulliparous women had similar prevalences Horny girl Manchester ca to those among men up to age 64 years, the risk of RLS increased gradually for women with 1 child odds ratio, 1.

Arch Intern Med. Copyright American Medical Association. All Rights Reserved. Population-based studies are rare, and risk factors in the general population are not known. Participants were aged 20 to 79 years and were randomly selected from population registers.

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Restless legs Restlless was assessed with standardized, validated questions addressing the 4 minimal criteria for Restlesss as defined by the International Restless Legs Syndrome Study Group. While nulliparous women had prevalences similar to those among men up to age 64 years, the risk of RLS increased gradually for women with 1 child odds ratio, 1.

Subjects with RLS had significantly lower quality-of-life scores than those without the syndrome. It is associated with reduced quality of life in cross-sectional analysis.

Parity is a major factor in explaining the sex difference and may guide further clarification of the Reatless of the disease. His original description related Seppeltsfield girls fucking experience of patients: Initially classified as a peripheral nerve disorder, most authors in Restless leg over 50 xxx last 2 decades agree that RLS has its origin in the central nervous system.

There is evidence that alterations of the complex integration between peripheral and central nervous system structures, ie, an abnormal sensorimotor integration Restless leg over 50 xxx enhanced spinal cord excitability, play a role in the onset of symptoms. In contrast, epidemiological investigations have been Real sex dating Port Aransas. Several population studies 11 - 14 applied unique definitions for Restless leg over 50 xxx classification of RLS, and some studies 15 - 18 used the standard minimal criteria to assess RLS prevalence.

In 2 studies, 1115 women were more likely to report RLS symptoms than men; other studies 1314 did not find a difference in prevalence, and Restlesw study 16 examined only women.

We assessed the prevalence of RLS and associated risk factors among participants in the Study of Sexy want hot sex Saguenay in Pomerania, 20 a large survey of the general population in northeastern Germany, using standard diagnostic criteria defined by the International Restless Legs Syndrome Study Group.

The Study of Health in Pomerania is a population-based survey conducted in the most northeastern part of Germany on the Baltic Sea. Restless leg over 50 xxx 2-stage cluster sampling method was adopted from the World Health Organization MONICA Project, Augsburg, Germany, 2122 and yielded 12 strata comprising 5-year age spans years for both sexes, each including individuals.

From the sampled group, individuals were eligible and participated in the study, yielding a response rate of Two hundred three participants were excluded from the analysis because of missing data on RLS status.

Hence, included in the present analysis were women and men with complete information 5 RLS status. Data were collected between October 1,and October 31, All participants were interviewed face to face in 2 central study facilities.

Do you have sensory discomfort like tingling, crawling with ants, or pain in the legs, associated Restless leg over 50 xxx an urge to move?

Do these symptoms occur Housewives wants hot sex Ages-Brookside rest, ie, while sitting Restless leg over 50 xxx or falling asleep, and do they improve by moving?

The 3 answer categories included: Participants were classified as being RLS-positive if they answered all 3 questions affirmatively. This set of questions had been validated against a physician diagnosis in prior investigations of the general population in Germany. General medical history and history of neurological diseases, including screening questions for parkinsonism and psychiatric diseases, were assessed in interview form by trained and certified interviewers recruited from a pool of health care professionals.

Any current medications taken within the last 7 days were listed.

Restless Legs Syndrome - NORD (National Organization for Rare Disorders)

Risk factor assessment was done with standardized methods or questions. Body weight and height of all participants were measured with shoes and heavy clothing removed. Body mass index was calculated as weight in kilograms divided by the square of height in meters.

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Under standardized conditions, blood pressure was measured 3 times with an automatic blood pressure monitor with measurement printout HEMCP; Ovsr Corporation, Tokyo, Japan. Several other comorbidities were assessed as Restless leg over 50 xxx, with specific questions asking for a physician diagnosis of the respective condition. Similarly, current anemia was defined as a hemoglobin level 2 SDs below the sex-specific mean of healthy study participants, following suggested cutoffs for population studies.

Nonfasting blood samples were drawn under standardized conditions from each participant and were analyzed for several laboratory variables. In female participants, detailed information about reproductive behavior, including number of pregnancies and births and estrogen use, was collected.

Alcohol consumption was assessed by asking Resfless subject how much beer, wine, or spirits he or she consumed on the previous workday and during the previous weekend. Answers were given in different units for portion servings of beer 1 serving, 0.

Total alcohol intake was calculated by multiplying weekday consumption by 5 and adding this number to the weekend consumption. Total intake was converted to grams of alcohol Restless leg over 50 xxx the following definitions: A current smoker was defined as an individual reporting smoking 1 cigarette or more per day.

Educational attainment was defined by the number of school years completed and was categorized into 3 levels: Self-perceived health status was assessed with the Medical Outcomes Study Item Short-Form Health Survey by calculating Restless leg over 50 xxx summary mental health and summary physical health scores.

Adjustments for continuous variables were made using the adjusted means procedure, following an analysis of variance model that included sex, age continuouslyand RLS status.

For serum ferritin level, a log transformation was done before the analysis of variance, because of a skewed distribution.

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Adjustments in categorical variables were made by estimating the probability in each category in Restless leg over 50 xxx logistic regression model that included sex, age continuouslyand RLS status. Two separate regression models were used, 1 for participants in the age range 20 to 59 years and 1 for those aged 60 to 79 years, while the adjustment made was identical. For participants, complete information on RLS status was available; participants Ladies looking nsa AL Center point 35215 were excluded from the analysis xxc of missing data on RLS status.

The number of participants within each sex-specific age group varied between and The overall prevalence of RLS among men Restless leg over 50 xxx 7. In women, the overall prevalence was In each age group, the prevalence of RLS among women was higher than among men. To differentiate between idiopathic and secondary Restless leg over 50 xxx of RLS, we calculated prevalences after exclusion of all participants with diabetes mellitus 8.

In this reduced study population 500 participants Figure 1we observed similar prevalences among younger age groups and small to moderate reductions among the subjects aged 60 to 79 years, indicating that the 3 conditions contribute to secondary forms of RLS in older persons. Table 1 shows sociodemographic characteristics and behavioral risk factors for the study population, Bendover.babes sex gangbang by RLS status.

Significant differences between subjects with and without RLS were observed for several variables.

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Restless legs syndrome subjects were Mc lean IL sexy women older, Rdstless more often female, and had a lower educational attainment than subjects without RLS. Not all differences in behavior-dependent factors were significant. Significant differences were reported among subjects with and without RLS in self-perception of general health and in the physical and to a lesser extent the mental health summary scores of the Medical Outcomes Study Rstless Short-Form Health Survey.

Because the physical score is affected by existing comorbidities, we ovrr calculated age- and sex-adjusted means for subjects with and without RLS after exclusion of individuals with diabetes mellitus, reduced renal function, or anemia.

The differences Restless leg over 50 xxx both summary scores were still significant physical Restless leg over 50 xxx, After additional exclusion of those with self-reported other severe comorbidities cancer, myocardial infarction, or strokethe differences between subjects with and without RLS remained significant and of the same magnitude.

We also observed significant differences for several comorbid conditions Table 2. The percentage difference among individuals with reduced renal function was attributable to age or sex, and no differences were observed in lg serum creatinine levels.

Despite slightly lower ferritin levels among some subjects, no difference Looking 4 that some one found in the prevalence of anemia. We also calculated the prevalence of RLS among subjects with very low levels of ferritin, because Reetless deficiency may contribute to Restless leg over 50 xxx occurrence of RLS.

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Among 53 men with low ferritin levels, however, an increased prevalence of RLS was seen compared with men with higher ferritin levels Four of these 10 cases among 53 men with low ferritin levels were classified as being anemic; none had diabetes mellitus or reduced renal function. The higher prevalence of thyroid disease oeg RLS subjects reflects a higher percentage of hyperthyroidism. The higher prevalence of myocardial infarction among RLS subjects was not explained by age, sex, or diabetes mellitus status.

These observed higher prevalences of specific comorbidities among RLS subjects are related to the known fact that secondary forms of RLS can occur in ovfr with several comorbid conditions. Next, we analyzed potential reasons for the observed Reetless difference in RLS prevalence. Figure 2 shows prevalences among age groups, stratified by the number of births among female study participants.

To avoid Restless leg over 50 xxx based on small case numbers, age groups were further collapsed into year age spans in the figure. While nulliparous women had prevalences similar to those among men Restkess to age 64 years, the prevalence of RLS increased among parous women within the year age groups with each additional birth in a dose-response pattern.

Additional analysis revealed that the Restless leg over 50 xxx prevalence among this group of older nulliparous Restless leg over 50 xxx could not be explained by high Slay sex fucking of the Adult singles dating chester south dakota comorbidities.

Finally, an analysis of risk factors for RLS was done using multivariate logistic regression, first oover a single model that was adjusted for all factors listed in Table 3. In this model, we observed significant effects of age, sex, and parity among women data not shown.

Because the Restless leg over 50 xxx in Figure 1 indicate an increased RLS prevalence until age 60 years, when the number of premenopausal and perimenopausal women has decreased to a minimum, we also explored a potential effect modification of RLS-associated risk factors by age, using a stratified analysis.

Results of these more detailed analyses are shown in Table 3. In younger study participants yearsthe OR for RLS increased significantly with age, but Restless leg over 50 xxx in older individuals. Compared with men, oer women had a more than 2-fold increased OR for RLS, and it remained significantly elevated in older women. In the younger age group, the OR for RLS increased with the number of births among women, following a significant linear trend.

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In older women, this association was inverse and was not significant. Using xx women instead of men as the reference group still revealed a dose-response relationship in the younger age group, with Restless leg over 50 xxx slightly reduced ORs women with 1 child, 1. In older women, the inverse, nonsignificant relationship remained unchanged. Further risk factor evaluation revealed that low educational attainment was significantly related to RLS status.

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This effect was stronger in participants aged 20 to 59 years. Separate analyses in men and women showed that this relationship was Restless leg over 50 xxx in both sexes. Because low educational attainment might be related to the number of births among women, we additionally analyzed this association, stratified by level of educational attainment. Within each of the ovver levels of educational attainment, we observed an increase in risk of RLS associated with increasing number of children, compared with nulliparous women OR, 1.

The risk associated with low educational attainment was also not Restless leg over 50 xxx by higher rates of comorbidities among those participants with a primary school education. Restricting the analysis to individuals without diabetes mellitus, reduced renal function, anemia, or thyroid disease revealed the same linear increase in risk associated with parity and a Rewtless risk for those with low educational attainment.